Updated: 2 days ago
Senolytics are small molecules that can selectively kill senescent cells which are old cells that drive aging-related processes and promote aging-related diseases. The selective eradication of senescent cells will increase your healthspan and you can use the next natural compounds to clean them from your organism. Next text, I going to talk deeply about these cells that can become cancer and the natural compounds you can use to get rid of them what going to help to reverse your biological age and extend your lifespan.
Animal studies have suggested that destroying senescent cells can slow down age-related physical decline and boost overall health. The accumulation of these cells increases with age, and they are found at sites of age-related pathologies. So there is a lot of value in getting rid of senescent cells with the compounds described below that will improve the ability of your body to clear them and improve your health condition.
But be aware that taking them will not make you younger, what does is a completely new lifestyle. It is like trying to fix fatigue by taking Ashwagha just because you read on this blog that increases your energy levels. While the reason can be vitamin B1, B12, or Magnesium deficiency and even taking these vitamins and minerals can not fix the problem because the reason could be in the absorption because your gut is leaky what is promoted by GMO food.
This is why the best method to reverse your age successfully is having an anti-aging health coach like me guiding you to reduce effectively your biological age to look younger, extend your health span, and avoid age-related diseases, like cancer, diabetes or Alzheimer's disease and here you can book a session with me in case you are interested and let´s begin.
What is a senescent cell ?
It is a cell with irreparable damage due to different factors that usually self-destructs through a programmed cell death mechanism called apoptosis. Normally cells divide finitely and for each division, the DNA tail shortens until it ends and then the cell can no longer divide, this last cell is called a senescent cell, and it self-destructs or is removed by the immune system.
But with age, the immune system declines, and cells become resistant to apoptosis.
These cells accumulate in the body and infect the surrounding cells, which causes them to proliferate even more. It has been demonstrated that senescent cells play a causal role in driving aging and age-related diseases using genetic and pharmacological approaches. External factors as pesticides, chemicals from the environment, and chemotherapy cause cellular damage and promote the proliferation of cellular senescence.
Normally and when we are young our cells can repair themselves but with the age, the repair system breaks down and cellular damage can have very detrimental effects on your health. But when the cell has irreparable damage it dies in a controlled manner through apoptosis if this not happen the cell can become a cancer cell that happens when the cell DNA is altered in a way that leads to increased proliferation. So the compounds below can help to avoid cancer as well by controlling improving the mechanism of the body for removing these cells.
When your body loses control over the proliferation of damaged cells, cancer and other diseases appear. What you can avoid by following the tips outlined in this article I wrote with habits, foods, and natural supplements you can take to prevent and control the proliferation of cancer cells. Also avoid medicaments, vaccines, pesticides, and detoxify your body often as it is described in this article with complete information about how to detox yourself.
The best method to remove senescent cells is avoiding food for 3 days or even 7 what drastically rejuvenates your organism and kills cancer cells by suppressing glucose which is their only source of energy. But please do not stop eating tomorrow for 3 days, it can destroy you completely and damage your skin. You need to prepare your body for optimal results.
In my yearly package, I prepare the people I coach for the ultimate goal which is a 3 day fast, and if they are warriors, 7 days without food. Which is optimal for activating stem cells to your benefit. And the secret that almost no one knows is that during your whole life your body has dormant stem cells and they can be activated to rejuvenate. A topic I will talk about in another article, so keep updated by subscribing to my newsletter right now.
Which are the best Natural Senolytics ?
It is the most potent natural senolytic compound that I know. Just check out this graphic with the best eleven senolytics and their positive impact in reducing senescent cells in mice. The result is amazing because fisetin stands out quite a lot from other senolytics such as Resveratrol, EGCG, and Quercitin, which are very famous anti-aging polyphenol enzymes found in plants. Even right now I feel the urgency to buy it for my parents.
Fisetin protects your cells from stress-related damage so they can run at full power. Fisetin regulates inflammatory pathways and deactivates several major inflammatory compounds. It also helps you make more glutathione, the most powerful anti-inflammatory substance in your body. Low inflammation means your cells can make more energy and you look better, feel better, and recover faster. Also, Milk thistle can help your liver to produce glutathione.
In this study, acute or intermittent treatment of progeroid and old mice with fisetin reduced senescence markers in multiple tissues. Fisetin reduced senescence in a subset of cells in murine and human adipose tissue, demonstrating cell-type specificity. Administration of fisetin to wild-type mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.
Is not well know the power of Luteolin as a senolytic. Something similar is happening with Gotu kola a herb that increases the size of the telomeres that no one is talking about which also helps to reduce senescent cells but as you see in this graphic, Luteolin is even a more powerful senolytic than Quercetin which is some of the most popular senolytics. If you read the ingredients of most senolytic activator supplements you will see mostly Quercetin or extract of green tea on their ingredients but never Luteolin.
What is Luteolin ?
Luteolin is a chemical classified as a citrus bioflavonoid with antioxidant and anti-inflammatory properties. These properties allow luteolin to scavenge reactive compounds containing oxygen and nitrogen, which can cause cellular damage. Luteolin is included in foods like oranges, broccoli, carrots, celery, parsley, peppermint, rosemary, and oregano.
The use of luteolin in health supplements primarily relates to its ability to manage inflammatory conditions. These uses include support for memory and the nervous system in addition to antioxidant effects. You can take this compound on a supplement like this one that contains also rutin which is a less potent senolytic. However, I recommend that you better consume these fruits, herbs, and vegetables. for example, celery juice is very popular for its great properties.
Curcumin, a natural compound extracted from turmeric with a broad range of biological and pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, and anti-cancer activities. Numerous studies suggest that curcumin has some health benefits in delaying aging and may be useful in preventing and treating age-related diseases.
The curcumin analog EF24 has the potential to be used as a novel senolytic agent for the treatment of age-related diseases. This is a novel potent and broad-spectrum senolytic agent that induces apoptosis in senescent cells and various tumor cells. These findings provide insights of the mechanisms by which curcumin and its analogs function as anti-aging agents.
In this study is screened several curcumin analogs its found that EF24 can selectively decrease the cell viability in a variety of senescent cells derived from various tissue origins and induced by different stresses. Its senolytic activity is likely attributable to the induction of SCs apoptosis and it is10-fold more potent in inducing cancer cell death than curcumin.
This is why Turmeric extract is one of the natural herbal remedies I recommend to prevent pancreatic cancer in this article I wrote. Which one of the most aggressive and lethal diseases due to its difficulty to be detected. So now you know great natural supplementation you can take with a lot of benefits and as I described before taking medicaments cause damage in cells that can lead to cancer.
Turmeric is also a great painkiller especially this product called CuraMed that I highly recommend you to take instead if you have arthritis, headaches, or pain instead of Ibuprofen or another painkiller because it not only will cause you to relieve naturally but as well will help rejuvenate your body, reduce inflammation and prevent or even kill cancer cells while the medications will intoxicate your liver and other areas of your organism.
It is time to talk about the most popular senolytic even if it is not so powerful as the ones exposed before in this article. In this video, Dr. Brad Stanfield explains perfectly what is a senescent cell but I do not recommend Dasatiniband and other medication. Companies study plants to copy from them molecules to create their toxic products to make money. Because when they find that some plant as turmeric can cure cancer instead of sharing the result of the study with society to benefit from it, they hide it and they create their drugs.
Most medications have serious side effects, and the simple products that everyone takes, such as Tylenol, can be fatal in high doses. On October 11, 2011, the U.S. Food and Drug Administration announced that Dasatinib may increase the risk of a rare but serious condition in which there is abnormally high blood pressure in the arteries of the lungs.
Some side effects of Dasitib are infection, suppression of the bone marrow (decreasing numbers of leukocytes, erythrocytes, and thrombocytes), hemorrhage (bleeding), pleural effusion (fluid around the lungs), dyspnea (difficulty breathing), musculoskeletal pain, tiredness, swelling in the legs and arms and in the face, fever and more, check them here.
Quercetin is a plant flavonol from the group of polyphenols found in many fruits, vegetables, leaves, seeds, and grains like red onions, tomatoes, broccoli, apples, and kale. These are common foods containing appreciable amounts of quercetin. It contains anti-cancer properties that might help prevent the spread of cancerous cells and tumor growth as all the senolytics described in this article and natural compounds described in this other article.
Quercetin has been shown to induce senescence and promote apoptosis in a multitude of cancer lines. Engaging senescence response is suggested as a key component for therapeutic intervention in the eradication of cancer. It also displays senescence delaying activity in primary cells and rejuvenating effects in senescent cells according to this study.
In addition, it can improve inflammation, blood pressure, exercise performance, blood sugar control and it is available in natural supplementation, however, I prefer to take it with my diet, but keep in mind that the amount of quercetin in food may depend on the conditions in which it was grown. For example, this study shows that organic tomatoes appear to have up to 79% more quercetin than conventionally grown tomatoes.
So, now you know which foods you can eat at dinner to clean up senescent cells during the night while you are sleeping. Keep in mind that having a deep sleep is strategic for reversing your biological age as well as intermittent fasting. And if you have problems to sleep could be due to deficiency of vitamin B1, B12, and Magnesium. But as well for the presence of stagnant energies due to electromagnetic pollution that you can clean with a Chi generator.
This device helped me to solve the insomnia I suffered for 15 years. I have the model Ju1000 and because I lost many days of my life due to my condition I decided to recuperate my wasted years by reversing my biological age. This is how I found David Sinclair and I became an anti-aging health coach helping people not only to age backward but as well to extend their healthspan through my coaching sessions you can book here.
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