Updated: Mar 17
One of the leading theories about aging is that it is caused by the decline of mitochondrial function, the bags within us that generate chemical energy called ATP throw proteins. The interesting fact is that mitochondria are free-living organisms inhabiting inside of each of our cells and each cell could have hundreds and even thousands of these organisms that divide and fuse. Which the cell is capable of destroying when they become toxic and improve the healthy ones. And it is mitochondrial dysfunction the origin of many aging-related diseases.
Over time a person starts to lose mitochondrial function, that is a fact. Around 60 and 70s is even worst and during 80 and 90s is much lower the mitochondrial function, so the body has less ATP and Scientists think that the main problem of aging-related diseases like diabetes, cancer or Alzheimer's disease is this loss of the ability of cells to make energy. That is why is essential to maintain these organisms living within our cells happy and healthy.
But it is possible to extend the optimal mitochondrial function for longer and I will talk about it in the next text but before it is important that I described the interaction between the nucleus of the cells with these organisms. And let me tell you that this article is part of the book I am writing right now with the method I use to reverse 10 years of the body age of the people I coach. So, be ready for this exquisite knowledge that will lead you to extend your healthspan.
For reversing your body age you need to work mainly in 4 areas. Which are maintaining your Mitochondria function properly, a readable DNA, long telomeres, and your body clean of senescent cells that normally destroy themselves through a process called apoptosis, but they are also removed by your immune system. Which weakens when you get older what increases the number of senescent cells, so they begin to accumulate in all the tissues of the body reflecting deterioration as consequence.
This time I going to focus on these essential and independent organisms living inside your cells, which are strategic to take care of for extending your healthspan. They are a type of primitive bacteria that merged in the cells eons ago that are feed with proteins by the nucleus of the cell. Both maintain a continuous communication through the genome of each one, both have their own DNA and this communication is reduced when the nucleus loses energy for the decline of NAD+ when you get older but NAD+ can be boosted with supplementation.
David Sinclair Professor of Genetics of Harvard Medical school observed that is possible to keep the nucleus feeding the mitochondria with proteins that rejuvenate your body as result. Your muscles will have still energy as when you were young by maintaining this constant communication by increasing the NAD+ inside your body which decreases when you get older. When he injected into rats NAD+ he discovered that the nucleus of the cells increases again the communication of the genome between the mitochondria and the nucleus again.
If you prevent that NAD+ from going down or reversed it, you going you restore the activity of Sirtuins what going to have a favorable impact on your mitochondria function and overall health. Because one of the major effects of Sirtuins is to keep mitochondria healthy and to boost the number of mitochondria but when NAD+ goes down because of aging the activity of sirtuins goes down as well and the activity of mitochondria decreases.
But below I going to tell you which supplement you can take and then I am going to describe other tips to maintain the mitochondria healthy and continuously renovating. Because when they are old the cells remove them and new ones are created, a process performed by the bacteria on your gut, which normally are killed by GMO food or the fluor and Chlorine available in most of the water people drink. This is why I recommend you to read this article where I am showing you how to create high-quality water to drink friendly for your gut.
The supplement that I going to describe below increases the size of the cancer cells as sugar does. So, in my yearly package, I work with the people I coach in killing any possible cancer cells that could be inside the body with some supplementation and intermittent fasting. Natural foods as purple veggies, mushrooms, Ginger, Chlorella, or Turmeric kill cancer cells as well as natural compounds found in herbs as Resveratrol and Quercetin. Which I recommend taking before NMN, a compound converted in your body into NAD+
NAD+ is some of the most important molecules of the planet which many living beings use to coexist and it is reduced when you get older affecting mitochondria function. NAD+ is required for energy production in any tissue. It is required to produce energy in the brain, in immune cells, in muscle tissue, and when energy levels decline as they do with age those tissues do not function properly as they do during youth when energy levels were maintained okay. This molecule is also required to maintain your genes of longevity pretty active.
The decline of NAD+ in your body produces mitochondrial dysfunction, cellular senescence, and altered epigenetics, and more. But there is a compound that you can take called Nicotinamide mononucleotide that is converted inside your body in NAD+ which maintains your mitochondria working well and the sirtuins repairing your DNA. This supplement has been shown to improve the way multiple tissues and cell types age, including, the heart, skeletal muscle, the brain, and stem cells.
David Sinclair found out that Nicotinamide Mononucleotide can help the nucleus of your cells maintain the energy levels they need to keep feeding the mitochondria. This compound is converted into NAD+ in your body through a series of chemical reactions that happen inside the cells, maintaining the nucleus active and in good communication with the Mitochondria through the genome. Which declined when you get older.
But also when you get older the mitochondria removal is reduced and your body fills up with toxic and less efficient mitochondria that normally are removed by your cells by a process called Mitophagy. When the mitochondria get old they are less efficient so they are recycled by the cell into new mitochondria but with age this process becomes sluggish, and cells end with bad mitochondria what leads to many problems for lack of ATP.
To maintain active mitophagy I recommend to the people I coach for reversing their body age to eat the most powerful antioxidant fruit on this planet, Pomegranate, or take it in extract. As you see in the video below Pomegranate helps the body activate mitophagy with help of the bacteria available in your gut, they work together so, it is important that you avoid drinking water with chlorine and fluor as well as GMO food which is included in many products on the supermarket with Corn syrup, Soja and other food with pesticides.
How to boost mitochondrial function ?
To maintain healthy your mitochondria practicing aerobic exercise is important and a nutritious diet without process sugar and carbs. Keeping GMO food away and pesticides, is mandatory for the health of your mitochondria and for avoidning aging. If you cannot afford organic food check this article with a strategic diet to detoxify your body. And sleeping well is important but if you have insomnia try to fix it with a Life energy generator, which is a device that cured the insomnia I suffered for 15 years, a condition that greatly deteriorated me.
Because viruses damage the mitochondria, it could be a good idea having a negative ionizer cleaning the air of your home from viruses and bacteria. They improve air quality and remove harmful pollutants. Also, by fasting you can increase the number of young and strong mitochondria, which helps to produce more cellular energy, reduces oxidative stress, and chronic disease development. And thing you can do in benefit of your mitochondria is taking the next supplements to maintain a good mitochondria function...
Coenzyme Q10 is a compound your body produces naturally present in all human cells, with the highest concentration in the mitochondria. It’s also sold in supplement form to treat various health conditions and ailments. It plays a fundamental role in energy production and acts as a powerful antioxidant, inhibiting free radical generation and preventing cell damage. There are two different forms of CoQ10 in your body: ubiquinone and ubiquinol.
Ubiquionol also has a 3.5 to 8 times higher bioavailability than ordinary Q10 (ubiquinone) and is therefore the much more effective form. And there is evidence that CoQ10 Ubiquinol supplementation positively affects mitochondrial deficiency syndrome and the symptoms of aging based mainly on improvements in bioenergetics. Cardiovascular disease and inflammation are alleviated by the antioxidant effect of CoQ10.
Coenzyme Q10 (CoQ10) is an essential electron carrier in the mitochondrial respiratory chain and an important antioxidant with a lot of anti-aging benefits like helping your skin remains young, improving male and female fertility, increasing exercise performance, and it plays a critical role in the protection of cell DNA and cell survival, both of which are strongly linked to cancer prevention and recurrence according to Healthline.
A very powerful enzyme that you should consider taking on supplementation especially if you suffer from diabetes. Because those with diabetes may have lower levels of CoQ10, and certain anti-diabetic drugs may further deplete body stores of this important substance. Both oxidative stress and mitochondrial dysfunction have been linked to the onset and progression of diabetes and diabetes-related complications. CoQ10 levels naturally deplete with age and to counteract the age-related depletion, it’s recommended to take 100–200 mg per day.
Creatine is a supplement used by fitness people to improve strength, increase lean muscle mass, and to help their muscles recover more quickly during exercise. But it has a very positive effect on the mitochondria, the battery of your whole body increasing energy production in the mitochondria. That extra energy enhances brain function, muscle strength, overall performance but as well some anti-aging effects.
Creatine supplementation is beneficial for your mitochondria, your brain and your muscles as well. It activates adenosine monophosphate kinase(AMPK), turns on genes that make new mitochondria, and releases enzymes that sweep away damaging free radicals. Processes that protect your mitochondria from damage, which is somehow beneficial for reverse aging.
According to this study Creatine Supplementation normalizes Mutagenesis of Mitochondrial DNA. These mutations play a role in neurodegeneration, normal aging, premature aging of the skin, and tumors. Mitochondrial mutagenesis as well as functional consequences could be normalized by increasing intracellular creatine levels. These data indicate that increase of the energy precursor creatine protects from functionally relevant, aging-associated mutations of mitochondrial DNA.
This supplement is safe for kids and even early adults, without doubt is some of the safest supplements out there. And vegetarians and vegans can benefit the most because they do not take any creatine throw their diet which is tipicaly found in meat and fish. But there are vegan friendly supplementation like this one which is made of two vegan creatine sources sarcosine and cyanamide together. And the right dose is between 1 to 5 grams per day.
It is the supplement I recommend you to take to maintain healthy magnesium levels and avoid Magnesium "oxide" and "aspartate" which are the most common types, which are available everywhere but by purchasing them you will waste your money. So, it is better to consume foods with magnesium like spinach, babanas, avocados, almonds, basil, cacao, brocoli, flax seeds, brasil nuts, sunflower seeds but taking supplementation can be strategic because nowadays the soil lacks minerals what reduces the magnesium content in food.
This mineral is very important to enhance exercise performance by increasing oxidative capacity, which is the ability of your mitochondria to produce ATP. Which is the energetic currency of your cells and it is very important that your ATP production execced your ATP consumption inorder to enhance your performance and avoid muscle fatigue.
According to Dr Patrick, There are two ways to increase your oxidative capacity. The first one is by increasing the number of Mitochondria and the second is by increasing the efficiency of your already existing mitochondria. And studies have shown that just one session of high-intesity interval training results in the production of new mitochondria but in order to make new mitochondria your existing mitochondria should copy their genome and this is done by enzymes that require magnesium as a cofactor what means that if your magnesium levels are low it going to be hard to make new mitochondria during exercise.
As you see Magnesium is important to maintain your mitochondria healthy and your energy levels high but not only that. Magnesium L-Threonate is an important component of structural proteins such as collagen (connective tissue, skin, tendons, ligaments, bones, teeth), protective glycoproteins such as mucins (components of mucous and mucous membranes), a building block of antibodies and a precursor of the amino acid glycine. The recommended daily allowance (RDA) for adults is 310–420 mg depending on age and gender.
Now you know anti-aging tips to maintain your mitochondria abundant inside your body and healthy to extend your healthspan. And if you are vegan feel free to consume all the supplements I am recomending on this blog which are based only on plants. And practice moderate exercise and avoid pollution which is strategic to age backward.
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